Major scientific weaknesses of astrology are:
Heliocentric - not a Geocentric system or in other words, the planets revolve around the sun - not the earth as the original astrologers thought.
Missing Planets - early astrologers believed there were only seven planets. All horoscopes were based on this belief.
Missing Horoscopes of the Artic - Above the arctic circle (66 degrees latitude astrologers find it nearly impossible to calculate what constellation or zodiacal point is rising on the horizon. So they have no planetary influence to determine their lives.
Speed and Refraction of Light - When calculating the planetary positions astrologers make no allowance for the velocity of light. Neither do the astrologers allow for the deflection of starlight. Because of these inaccuracies precise astrological calculations are not possible.
Astrology has no answer to the problem of multiple births (for example; twins, triplets, quadruplets and etc.).
Different astrologers given different readings for the same person.
Astrologers have a problem with catastrophes where large numbers of people die at the same time.
And much more.
Astrology is unreliable and not worthy of anyone's trust.